Creamed Chicken and Biscuits Casserole: A Southern Comfort Classic
If you’re craving warm, hearty, and satisfying comfort food, this Creamed Chicken and Biscuits Casserole is exactly what you need! Inspired by Grandma’s Southern-style chicken and biscuits, this dish combines tender, juicy chicken, a creamy, cheesy sauce, and buttery, golden biscuits for a meal that’s pure comfort in every bite.
Perfect for family dinners, potlucks, or cozy nights in, this one-pan wonder is easy to make and packed with rich, savory flavors. Serve it with a fresh green salad or enjoy it on its own—either way, it’s a crowd-pleaser!
Why You’ll Love This Creamed Chicken and Biscuits Casserole
Classic Southern comfort – A warm, hearty dish that feels like home.
One-pan meal – Minimal dishes, maximum flavor!
Super creamy & cheesy – A rich, velvety sauce with melty cheddar.
Quick & easy – Made with simple, pantry-friendly ingredients.
Perfect for meal prep – Make ahead and reheat for busy weeknights!
Ingredients & Their Role in the Recipe
Each ingredient plays a crucial role in creating layers of flavor and texture:
For the Creamy Chicken Filling:
1 ½ teaspoons butter – Adds richness and helps sauté the onions.
1 small onion, chopped – Provides a mild sweetness and depth of flavor.
2 pounds cooked chicken, cut or shredded – The star of the dish! Use rotisserie chicken for convenience.
1 can cream of chicken soup – The base of the creamy sauce, adding thickness and flavor.
½ cup mayonnaise – Gives the casserole an extra creamy, tangy richness.
1 cup milk – Helps to create a smooth, pourable consistency.
½ cup roasted red pepper, chopped – Adds a sweet, smoky flavor and a pop of color.
For the Biscuit Topping:
1 ½ cups mild cheddar cheese, shredded – Melts beautifully for a cheesy, gooey bite.
1 can refrigerated biscuit dough – The perfect buttery, flaky topping!
Step-by-Step Instructions for Creamed Chicken and Biscuits Casserole
Step 1: Preheat & Prep
Preheat your oven to 350°F (175°C).
Grease the bottom and sides of a 9×13-inch baking dish to prevent sticking.
Pro Tip: Using rotisserie chicken saves time and adds extra flavor!
Step 2: Prepare the Creamy Chicken Mixture
In a large skillet, melt butter over medium heat.
Add the chopped onion and sauté until soft and translucent (about 3-4 minutes).
In a large bowl, mix together the cooked chicken, sautéed onions, cream of chicken soup, mayonnaise, milk, and roasted red peppers.
Stir well to combine until the mixture is smooth and evenly coated.
Step 3: Assemble & Bake
Pour the creamy chicken mixture into the prepared baking dish.
Bake for 15 minutes, then remove from the oven.
Sprinkle 1 cup of shredded cheddar cheese evenly over the baked filling.
Pro Tip: This short baking time helps thicken the sauce before adding the biscuits.
Step 4: Add Biscuits & Cheese
Layer the biscuit dough over the cheese-covered chicken mixture.
Sprinkle the remaining cheddar cheese on top of the biscuits.
Return the dish to the oven and bake for another 20 minutes, or until the biscuits are golden brown and cooked through.
Step 5: Let It Rest & Serve
Remove from the oven and let it sit for 5 minutes to allow the sauce to thicken.
Serve warm on its own or with a simple side salad for a complete meal.
Serving Suggestions
This casserole is hearty enough to be a meal on its own, but you can also pair it with: ✔ A fresh green salad – To add a refreshing contrast.
Steamed vegetables – Such as green beans, broccoli, or carrots for extra nutrition.
Mashed potatoes – If you love extra creamy comfort food.
Pro Tips for the Best Creamed Chicken and Biscuits Casserole
Use pre-cooked or rotisserie chicken – Saves time and adds extra flavor.
Don’t overbake – Biscuits should be golden brown, but not too dark!
For extra flavor, add garlic powder, paprika, or fresh thyme to the chicken mixture.
Let it rest before serving – This allows the creamy sauce to thicken up beautifully.
Storage & Reheating Tips
Refrigerator: Store leftovers in an airtight container in the fridge for up to 3 days.
Freezer: Freeze in a sealed, freezer-safe container for up to 3 months.
To Reheat: Warm in the oven at 325°F (160°C) for 15 minutes, or microwave individual portions.
Why This Casserole Is a Must-Try
Ultimate comfort food – Rich, creamy, cheesy, and satisfying.
Crowd-pleaser – Perfect for family dinners or potlucks.
Easy one-pan meal – Minimal prep, maximum flavor!
Customizable – Add extra veggies or seasonings to make it your own.
Final Thoughts: The Best Creamed Chicken and Biscuits Casserole
This Creamed Chicken and Biscuits Casserole is a Southern classic that brings together juicy chicken, creamy sauce, and buttery biscuits for a meal that warms your soul. It’s simple, delicious, and perfect for busy weeknights or lazy weekends.
Try this recipe tonight and experience the irresistible flavors of this homemade comfort dish!